Efficacy and Safety of Glucosamine and Chondroitin for the Treatment of Osteoarthritis
Objective: To evaluate the symptomatic efficacy and safety of oral symptomatic slow-acting drugs (SYSADOA) in the treatment of knee and/or hip osteoarthritis such as chondroitin, glucosamine, and combination therapy with chondroitin plus glucosamine.
Methods: We searched the electronic database including PubMed, Embase, Cochrane Library and reference lists of related articles published from inception to May 22, 2018. An updated meta-analysis was performed to evaluate the effectiveness of these slow-acting drugs for osteoarthritis.
Results: 26 articles describing 30 studies met our inclusion criteria and were included in the meta-analysis. Estimates between chondroitin and placebo showed that chondroitin can relieve pain symptoms and improve function. Compared with placebo, glucosamine only proved to have a significant effect on stiffness improvement.
Conclusions: Given the effectiveness of these symptomatic slow-acting drugs, oral chondroitin is more effective than placebo in relieving pain and improving physical function. Glucosamine showed beneficial effect on hardness outcome.
*1- https://pubmed.ncbi.nlm.nih.gov/29980200/
Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled
*2- https://pubmed.ncbi.nlm.nih.gov/25629804/
Chondroitin for osteoarthritis
*3- https://pubmed.ncbi.nlm.nih.gov/16309928/
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
*4- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/
Boswellia Serrata, A Potential Anti-inflammatory Agent: An Overview
*5- https://pubmed.ncbi.nlm.nih.gov/1262245
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled
*6- https://pubmed.ncbi.nlm.nih.gov/25312172/
Analgesic effects of crude extracts and fractions of Omani frankincense obtained from traditional medicinal plant Boswellia sacra on animal
*7- https://pubmed.ncbi.nlm.nih.gov/25081082/
Beneficial effects of hyaluronic acid
*8- https://pubmed.ncbi.nlm.nih.gov/33039536/
A review on the wide range applications of hyaluronic acid as a promising rejuvenating biomacromolecule in the treatments of bone related diseases
